Curing the COVID-19 Infection: where we have reached?

The looming threat of the COVID-19 outbreak, around the world, has united the entire global medical science community for finding out the treatment for this pandemic. A viable solution sooner is a need of the hour, before this viral outbreak claims more human lives.

Despite the fact there being no specific treatment available for the COVID-19, various anti-retroviral drugs are being administered to the patients for their treatment. The current treatment mainly focuses towards the symptomatic and respiratory support to the infected patient.  Antiviral drugs such as oseltamivir, peramivir, zanamivir, ganciclovir, acyclovir, and ribavirin etc., which are mainly used for the influenza viruses have not shown any promising result against COVID-19 and are declared invalid. 

However, Remdesivir (GS-5734) a broad-spectrum antiviral drug having activity against several RNA viruses, has been found to be effective in certain cases and is being investigated for its potential in COVID-19 related treatments. Another proposed treatment is the use of Chloroquine, which has been used for treating malaria for several years. However, the exact mechanism of action of Chloroquine for the treatment of virus-related diseases is not clear, apparently, its immunomodulatory role, viral receptor modification and inhibition of replication process in the viruses could be the ways this drug acts against the viruses. 

Evidently a combination of Remdesivir & Chloroquine has shown promising results against COVID-19 in the preclinical studies. In addition, lopinavir/ritonavir are two other widely used drugs for the treatment of COVID-19 related infections and have shown promising results in reducing the viral load. 

Despite the fact that above mentioned drugs are being widely used as a supporting treatment, however, we require stronger clinical data for their establishment as a definite drug for the treatment.

Furthermore, significant efforts are being made for the vaccine development, however, there has not been any greater success achieved so far in this direction. Thus, in the present case scenario taking adequate preventive measures such as maintaining proper hygiene and social distancing, appears to be a suitable solution to prevent the worsening of this pandemic. 

Reference:

  • Yan-Rong Guo, Qing-Dong Cao, Zhong-Si Hong, Yuan-Yang Tan, Shou-Deng Chen, Hong-Jun Jin, Kai-Sen Tan, De-Yun Wang and Yan Yan. The origin, transmission and clinical therapies on coronavirus disease 2019(COVID-19) outbreak – an update on the status. Guo et al. Military Medical Research (2020) 7:11.
  • Feng He, Yu Deng, Weina Li. Coronavirus Disease 2019 (COVID-19): What we know?. J Med Virol.
  • Alimuddin Zumla, Jasper F. W. Chan, Esam I. Azhar, David S. C. Hui and Kwok‑Yung Yuen. Coronaviruses – drug discovery and therapeutic options. Reviews.

Leave a Reply

Your email address will not be published. Required fields are marked *